Inside Cancer

Hodgkin’s lymphoma or Hodgkin’s disease is a rare for of cancer which is characterized by orderly growth of malignant cells of the lymphatic system. Described for the first time by Thomas Hodgkin in 1832, this disease primarily affects the lymph nodes and later spreads to other parts of the lymphatic system.

The most significant characteristic of Hodgkin’s lymphoma is presence of malignant B-cells with unique characteristics. These cells are called as Reed-Sternberg cells. Hodgkin’s lymphoma mainly occurs in individuals with depleted immune system and persons infected with viruses including HIV, Epstein-Barr virus and HTLV-I. Epidemiology of this disease is unique. The frequency of Hodgkin’s lymphoma is predominant in two separate age groups. These include individuals between 15-35 years of age and individuals above 55 years of age.

Hodgkin’s lymphoma is primarily classified into classical Hodgkin’s lymphoma (CHL), nodular sclerosis (NS), lymphocyte predominance (LP), mixed cellularity (MC), Lymphocyte depleted (LD) and nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL) depending on the Reed-Sternberg cell morphology. The most common symptom of Hodgkin’s disease is swelling in the lymph nodes of the neck and chest. Other noticeable symptoms include enlarged spleen, swollen liver, fever, excessive sweating, fatigue, abnormal weight loss and itchy skin. The disease could be medically diagnosed through microscopical examination of Reed-Sternberg cells during biopsy. Other diagnostic methods include physical examination, chest X-rays, blood cell counts, and CT scan and MRI scan of the lymphatic system, PET scanning, gallium scanning and bone marrow aspiration.

Hodgkin’s lymphoma is one of the first cancers to have been cured using radiation therapy. Other therapeutic approaches include chemotherapy, bone marrow and peripheral blood transplantation and immunotherapy. The common chemotherapeutic regimens followed for the treatment of Hodgkin’s lymphoma include ABVD (Adriamycin, bleomycin, vinblastine, dacarabzine), BEACOPP (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, prednisone), COPP/ABVD, MOPP (mechlorethamine, oncovin, procarbazine, prednisone) and Stanford V.